Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy
Apr 1 2021
Children and young adults who receive CAR T-cell therapy for the most common childhood cancer - acute lymphoblastic leukemia - suffer remarkably fewer relapses and are far more likely to survive when the treatment is paired with a subsequent stem cell transplant, a new study finds.
Daniel Trey Lee is conducting pioneering clinical research in the battle against childhood cancer. Image Credit: UVA Health
The research, with an average follow up of nearly five years, suggests that stem cell transplants offer long-term benefits for young patients who receive the cutting-edge immunotherapy. CAR T-cell therapy results in complete remission in 60%-100% of patients initially, but the relapse rate is high. However, among those who received a stem cell transplant after CARs, the relapse rate was less than 10% two years later.
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Reports have been flying thick and fast suggesting and speculating that Alia Bhatt has contracted COVID. Clearly, the second wave of this disease seems to be scarier than the first. ETimes got in touch with FWICE, (Federation of Western India Cine Employees), General Secretary Ashok Dubey, who said, “Yes, I have got to know that Alia has tested positive for COVID”.
Dubey explained how he got the information. “A technician from Gangubai Kathiawadi unit called me a little before 9pm to say that they have packed up for the day. When I asked him why, he said that a lead actor of the film had tested positive. Then, I called Chetan who heads the production responsibilities of Sanjay Leela Bhansali Productions who informed me that it was Alia who had been infected”.
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It may be 1 April, but the Official Charts Company can confirm this is not actually a joke.
Mr Brightside by The Killers continues to prove itself the chart hit that can’t be kept down. This week the track logs a record-breaking 260th non-consecutive week – or a full FIVE YEARS - on the Official UK Singles Chart Top 100, according to Official Charts Company records.
No song in UK chart history has notched up anywhere near as many weeks in the Top 100 - the closest is Snow Patrol’s 2006 Top 10 hit Chasing Cars, at 166 weeks.
Mr Brightside has become the stuff of legend on the Official Chart. The indie-pop anthem spent just four weeks in the Top 100 upon its original 2004 release, peaking at Number 10. The years since have seen it become a staple at many a party or club night, helping it rack up lots of streams and downloads every week.
Image courtesy of Amtrak Proposed Amtrak routes in Pennsylvania as part of its Vision 2035 plan. Dark blue is existing service, orange is enhanced service, and light blue is new service. On March 31, passenger train provider Amtrak released its 2035 Vision plan to expand and improve rail service throughout America, including more than 30 new routes and improving service on more than 20 existing routes. And Pennsylvania is getting a lot of train attention, particularly the eastern half of the commonwealth, and the Pittsburgh area would also see new routes and expanded service, too. “With a growing and diverse population, a global climate crisis and longer traffic jams, America needs a rail network that offers frequent, reliable, sustainable, and equitable service,” reads Amtrak’s vision plan.